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Home - Products - Membrane Transporter/Ion Channel - P-glycoprotein - Tariquidar methanesulfonate hydrate

Tariquidar methanesulfonate hydrate

CAS No. 625375-83-9

Tariquidar methanesulfonate hydrate ( XR 9576;XR-9576;XR9576 )

Catalog No. M15368 CAS No. 625375-83-9

A potent, specific P-gp inhibitor with Kd of 5.1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tariquidar methanesulfonate hydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, specific P-gp inhibitor with Kd of 5.1 nM.
  • Description
    A potent, specific P-gp inhibitor with Kd of 5.1 nM; potentiates the cytotoxicity of several drugs including doxorubicin, paclitaxel, etoposide, and vincristine in a panel of human MDR cell lines at 25-80 nM; exhibits potent i.v. and p.o. activity without apparently enhancing the plasma pharmacokinetics of paclitaxel or the toxicity of coadministered drugs.Breast Cancer Phase 2 Discontinued
  • Synonyms
    XR 9576;XR-9576;XR9576
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    P-glycoprotein
  • Recptor
    P-glycoprotein
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    625375-83-9
  • Formula Weight
    892.99
  • Molecular Formula
    C40H52N4O15S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 296 mg/mL; H2O: < 8.9 mg/mL
  • SMILES
    COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC.CS(=O)(=O)O.CS(=O)(=O)O.O.O.O
  • Chemical Name
    3-Quinolinecarboxamide, N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-, methanesulfonate, hydrate (1:2:3)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Martin C, et al. Br J Pharmacol. 1999 Sep;128(2):403-11.
2. Mistry P, et al. Cancer Res. 2001 Jan 15;61(2):749-58.
3. Walker J, et al. Eur J Cancer. 2004 Mar;40(4):594-605.
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